I attempted to log into a new installation of SSRS Manager and received an error : Unable to connect to remote server .
This is what I did to fix the issue:
I went to C:\Program Files\Microsoft SQL Server\MSRS10_50.MSSQLSERVER\Reporting Services\ReportServer\rsreportserver.config file.
I changed the value for the SecureConnectionLevel key to 0. It was previously set to 2.
<Add Key ="SecureConnectionLevel" Value="0"/>
I logged back into SSRS Manager and was able to after that.